4.4 Article

Efficient Synthesis of 6-Aryl-2-chloronicotinic Acids via Pd Catalyzed Regioselective Suzuki Coupling of 2,6-Dichloronicotinic Acid

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JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 45, 期 6, 页码 1847-1849

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WILEY
DOI: 10.1002/jhet.5570450646

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  1. Shanghai Commission for Science and Technology [06Pj14034, 06DZ19002]
  2. Ministry of Education [106078]
  3. Ministry of Science and Technology of China [2003CB716600]

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A regioselective Suzuki coupling of 2,6-dichloronicotinic acid with aryl boronic acids to synthesize 6-aryl-2-chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh3)(4).

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