期刊
JOURNAL OF HEPATOLOGY
卷 61, 期 -, 页码 S3-S13出版社
ELSEVIER
DOI: 10.1016/j.jhep.2014.06.031
关键词
Hepatitis C virus; Viral life cycle; Virus entry; Virus-host interactions
资金
- French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
- ANR through ERA-NET Infect-ERA program [ANR-13-IFEC-0002-01]
- European Research Council [ERC-2008-AdG-233130-HEPCENT]
- LabEx ECOFECT of Universite de Lyon [ANR-11-LABX-0048]
- ANRS
- Agence Nationale de la Recherche (ANR) [ANR-13-IFEC-0002] Funding Source: Agence Nationale de la Recherche (ANR)
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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