期刊
JOURNAL OF HEPATOLOGY
卷 60, 期 5, 页码 1040-1045出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2014.01.009
关键词
Non-alcoholic fatty liver disease; Hypertension; Type 2 diabetes; Obesity; Insulin resistance; Metabolic syndrome.
资金
- Samsung Biomedical Research Institute [SBRI C-B1-114-1]
- Southampton National Institute
Background & Aims: Approximately 50% of hypertensive patients have non-alcoholic fatty liver disease (NAFLD), but whether change in fatty liver status over time modifies risk of developing hypertension is uncertain. Our aim was to determine whether a change in fatty liver status (either development of new fatty liver, or resolution of existing fatty liver) over five years modified risk of incident hypertension at five year follow-up. Methods: 11,448 patients without hypertension were examined at baseline and at five year follow-up, using a retrospective cohort study design. Fatty liver status (absent or present) was assessed at baseline and follow-up using standard ultrasound criteria. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for incident hypertension at follow-up were estimated controlling for potential confounders, compared to the reference group (patients who did not have fatty liver at either baseline or follow-up). Results: 911 patients developed incident hypertension. Incident fatty liver developed during follow-up in 1418 patients and fatty liver at baseline resolved during follow-up in 684 patients. Developing incident fatty liver was associated with incident hypertension, even after adjustment for multiple confounders (aOR = 1.60 (95% CI 1.30, 1.96; p < 0.001). Further adjustment for change in body mass index between baseline and follow-up only slightly attenuated this association (aOR = 1.36 (95% CI 1.10, 1.67; p = 0.004). With resolution of fatty liver at follow-up, risk of incident hypertension was not different from the reference group (aOR = 1.21 (95% CI 0.90, 1.63; p = 0.21). Conclusions: Development of incident fatty liver is associated with increased risk of hypertension. (c) 2014 European Association for the Study of the Liver. Published by Elsevier B. V. All rights reserved.
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