期刊
JOURNAL OF HEPATOLOGY
卷 60, 期 1, 页码 118-126出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2013.08.022
关键词
Hepatocellular carcinoma; TACE; Prognosis; HCC; ART score
资金
- Bayer Schering Pharma
- Roche
- Bayer
- Schering Pharma
- Lilly Pharma
- Boehringer Ingelheim
Background & Aims: Recently, we developed the ART score (assessment for re-treatment with TACE) to guide the decision for a second transarterial chemoembolization (TACE-2) in patients with hepatocellular carcinoma (HCC). Patients with an ART score of 0-1.5 points gained benefit from a second TACE session, while patients with an ART score >= 2.5 points did not. Here, we investigated (1) the prognostic significance of the ART score prior to the third (TACE-3) and fourth TACE (TACE-4), and (2) the feasibility of an ART score guided re-treatment strategy by sequential assessment of the ART score in HCC patients treated with multiple TACE sessions. Methods: 109 patients, diagnosed with intermediate stage HCC and treated with >= 3 TACE sessions between January 1999 and December 2009 at the Medical Universities of Vienna and Innsbruck, were included. The ART score prior to each TACE session was assessed in comparison to the TACE naive liver. The prognostic performance of the ART score before TACE-3 and 4 was evaluated with and without stratification based on the ART score prior to the respective last intervention. Results: The pre-TACE-3 ART score discriminated two groups with different prognosis and remained a valid predictor of OS independent of Child-Pugh score (5-7 points), CRP-levels and tumor characteristics. Even in patients with an initially beneficial ART score (0-1.5 points) before TACE-2, repeated ART score assessment before TACE-3 identified a subgroup of patients with dismal prognosis (median OS: 27.8 vs. 10.8 months, p <0.001). Similar results were observed when the ART score was applied before TACE-4. Conclusions: The sequential assessment of the ART score identifies patients with dismal prognosis prior to each TACE session. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据