期刊
JOURNAL OF HEPATOLOGY
卷 58, 期 1, 页码 184-189出版社
ELSEVIER
DOI: 10.1016/j.jhep.2012.07.026
关键词
Hepatitis C; Vitamin D; 25(OH)D; 1,25(OH)(2)D; Inflammation
Vitamin D is increasingly becoming recognized as an important physiological regulator with pleiotropic functions outside of its classical role in skeletal homeostasis. A growing body of clinical evidence highlights the prevalence and risks of vitamin D deficiency in patients suffering from chronic hepatitis C infection, and vitamin D supplementation has been proposed as an adjunct to current standards of care. This review considers the experimental evidence for the anti-inflammatory, antifibrotic and antiviral effects of vitamin D, and discusses the therapeutic potential of vitamin D supplementation to protect against liver disease progression and improve responses to treatment. (C) 2012 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
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