期刊
JOURNAL OF HEPATOLOGY
卷 54, 期 1, 页码 153-159出版社
ELSEVIER
DOI: 10.1016/j.jhep.2010.05.037
关键词
Non-alcoholic fatty liver disease; Cholesterol absorption; Cholesterol synthesis; Lathosterol; Sitosterol; Cholestanol; Magnetic resonance spectroscopy
资金
- Academy of Finland
- Sigrid Juselius Foundation
- Novo Nordisk Foundation
- Biomedicum Helsinki Foundation
- Paulo Foundation
- Orion-Farmos Research Foundation
- Helsinki University Central Hospital
- European Commission [LSHM-CT-2005-018734]
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with impaired glucose and lipoprotein metabolism. However, the metabolism of cholesterol in NAFLD remains unexplored. We investigated how fatty liver influences cholesterol metabolism in 242 non-diabetic subjects. Methods: Liver fat content was measured with proton magnetic resonance spectroscopy. Cholesterol metabolism was assayed with serum non-cholesterol sterols, surrogate markers of cholesterol synthesis and absorption. The analyses were performed with gas-liquid chromatography. Results: A total of 114 subjects had NAFLD and 128 subjects had normal liver fat content. Non-cholesterol sterols reflecting cholesterol synthesis (cholestenol, desmosterol, and lathosterol) were higher, and those reflecting cholesterol absorption (cholestanol and plant sterols) were lower in subjects with NAFLD than in controls, independent of body mass index. Liver fat content was positively associated with markers of cholesterol synthesis (r = from 0.262 to 0.344, p < 0.001 for all) and inversely associated with markers of cholesterol absorption (r = from -0.299 to -0.336, p<0.001 for all). In the entire study group, synthesis and absorption markers were interrelated, indicating that the homeostasis of cholesterol metabolism was maintained. LDL cholesterol was similar in the two groups. Conclusions: We demonstrated that although LDL cholesterol concentrations are unchanged, cholesterol metabolism in NAFLD is characterized by increased synthesis and diminished absorption of cholesterol. These changes are associated with liver fat content independent of body weight. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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