期刊
JOURNAL OF HEPATOLOGY
卷 54, 期 6, 页码 1263-1272出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2010.12.004
关键词
Bile acids; Diabetes; Energy homeostasis; FXR; GLP-1; G-protein coupled receptor; Nuclear receptors; TGR5
资金
- Swiss National Science Foundation
- ERC
- NIH
- Nestle
- Ecole Polytechnique Federale de Lausanne
- FEBS
- CONACYT
- AXA
Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function as signaling molecules capable to activate specific receptors. These BA receptors are not only important in the regulation of bile acid synthesis and their metabolism, but also regulate glucose homeostasis, lipid metabolism, and energy expenditure. These processes are important in diabetes and other facets of the metabolic syndrome, which represents a considerable increasing health burden. In addition to the function of the nuclear receptor FXR alpha in regulating local effects in the organs of the enterohepatic axis, increasing evidence points to a crucial role of the G-protein coupled receptor (GPCR) TGR5 in mediating systemic actions of BAs. Here we discuss the current knowledge on BA receptors, with a strong focus on the cell membrane receptor TGR5, which emerges as a valuable target for intervention in metabolic diseases. (C) 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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