期刊
JOURNAL OF HEPATOLOGY
卷 52, 期 4, 页码 616-619出版社
ELSEVIER
DOI: 10.1016/j.jhep.2009.12.017
关键词
CD8 T cell exhaustion; Chronic hepatitis B virus infection; Immunotherapy
资金
- Medical Research Council [G0801213] Funding Source: Medline
- MRC [G0801213] Funding Source: UKRI
- Medical Research Council [G0801213] Funding Source: researchfish
There is a pressing need to develop new immunotherapeutic interventions in chronic hepatitis B virus (HBV) infection in order to limit the high costs and risks of toxicity or viral resistance associated with maintenance antiviral treatment. Here we review recent advances in our understanding of the molecular defects underlying the profound T cell depletion characteristic of these patients. We propose that T cells are driven to apoptosis by the combination of persistent, high antigen load and excessive inhibitory signals encountered in the hepatic microenvironment. The feasibility of boosting sustained antiviral control by targeted reversal of key tolerising mechanisms is discussed. (c) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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