期刊
JOURNAL OF HEPATOLOGY
卷 52, 期 3, 页码 455-462出版社
ELSEVIER
DOI: 10.1016/j.jhep.2009.12.002
关键词
Nuclear receptor; Ligand; Gene expression; Cholestasis; Fatty liver; Fibrosis
资金
- NIH
- Falk Foundation
- Intercept
- EASL
- AASLD
- KENES
- Austrian Science Foundation [P18613-B05, F3008-B05]
- NIH/NIDDK [DK56239]
- Austrian Science Fund (FWF) [P18613] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [F 3008] Funding Source: researchfish
A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports the highlights of the conference and summarizes the main conclusions emphasizing the relevance for clinical and experimental hepatology. The confluence of nuclear receptors as central transcriptional regulators, acting as sensors and adaptors to many of the small molecules present in the intracellular milieu of all the cells of the liver, provides a current framework to address a broader physiological understanding of the liver. The next stage will be the design and testing of safe and effective therapeutics.
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