期刊
JOURNAL OF HEPATOLOGY
卷 50, 期 5, 页码 1035-1042出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2008.12.025
关键词
Heritability; ALT; Insulin; Liver fat; NAFLD; Twins
资金
- European Commission [LSHM-CT-2005-018734]
- Academy of Finland [100499, 205585, 118555]
- Biovitrum Foundation
- Sigrid Juselius Foundation
- Liv och Halsa Foundation
- Helsinki University Central Hospital
- Research Foundation of the Orion Corporation
- Jalmari and Rauha Ahokas Foundation
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- National Institute of Alcohol Abuse and Alcoholism
- Academy of Finland Centre of Excellence in Complex Disease Genetics
- Academy of Finland (AKA) [118555, 118555] Funding Source: Academy of Finland (AKA)
Background/Aims: This study aimed to determine the heritability of serum alanine aminotransferase (S-ALT) and fasting serum insulin (fS-insulin) concentration as well as determine the association of these measures with liver fat content in young adult monozygotic (MZ) and dizygotic (DZ) twins. Methods: Three hundred and thirteen individual twins were recruited from a population-based cohort (n = 4929). The study subjects represented a wide range of body mass indexes (BMI), were free of any diseases or regular medications and had an intake of less than two drinks of alcohol/day. To verify that S-ALT is a marker of liver fat, it was measured by proton magnetic resonance spectroscopy ((1)H MRS) in 66 subjects. Heritability estimations were performed using BMI-and gender-adjusted values. Results: Intro-pair correlations were significantly higher in the MZ twins than the DZ twins for both S-ALT (0.65 for MZ and 0.04 for DZ) and tS-insulin (0.58 and 0.34, respectively). Heritability of S-ALT was 55%, and that of IS-insulin 61%. In the 66 subjects S-ALT (r = 0.70 for women and r = 0.50 for men, p <= 0.01 for both) and fS-insulin (r = 0.58 and r = 0.59, respectively, p <= 0.01 for both) concentrations correlated significantly with liver fat content. Conclusions: These twin data suggest that approximately 60%, of the variation in S-ALT, a marker of liver fat content, is genetically determined. (c) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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