期刊
JOURNAL OF HEPATOLOGY
卷 48, 期 5, 页码 829-834出版社
ELSEVIER
DOI: 10.1016/j.jhep.2008.01.016
关键词
non-alcoholic fatty liver disease; NASH; NASH CRN; NAS; steatosis
资金
- NIDDK NIH HHS [U01 DK061728, U01 DK 061734, U01 DK061730, U01 DK 061737, U01 DK061738, U01 DK 061713, U01 DK061718, U01 DK061734, U01 DK061731, U01 DK 061732, U01 DK061737-04, U01 DK 061718, U01 DK061737, U01 DK061713, U01 DK061732, U01 DK 061728, U01 DK 061730, P30 DK056341-08, P30 DK056341, P30 DK056341-07, U01 DK 061738, U01 DK 061731] Funding Source: Medline
Background/Aims: The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied. Methods: We conducted a study to examine the relationship of severity and zonal location of steatosis to the presence of NASH and to other histological features that define NASH in adult patients with NAFLD. Steatosis was graded as mild, moderate or severe. We examined the relationship between severity and zonal location of steatosis and the following: lobular inflammation, presence of ballooning, Mallory bodies, fibrosis score, and definite steatohepatitis. Results: Mild, moderate and severe steatosis was present in 44%, 31% and 25% of biopsies, respectively. Definite steatohepatitis was present in 59% and advanced fibrosis in 29% of liver biopsies. Increasing levels of steatosis severity were positively associated with lobular inflammation (p < 0.0001), zone 3 fibrosis (p < 0.001), and definite steatoliepatitis (p = 0.02), but were unrelated to ballooning, Mallory bodies, or advanced fibrosis. As compared to zone 3 steatosis, pan-acinar steatosis was more often associated with ballooning, Mallory bodies, and advanced fibrosis. Conclusions: Patients with severe steatosis are more likely to have steatohepatitis. More studies are needed to confirm this observation and to explore its significance. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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