期刊
JOURNAL OF HEPATOLOGY
卷 49, 期 2, 页码 295-298出版社
ELSEVIER
DOI: 10.1016/j.jhep.2008.03.033
关键词
hepatitis C non-responders; retreatment; insulin resistance; pioglitazone; chronic hepatitis
资金
- Swiss National Science Foundation [320000-116544]
- Leenaards Foundation
- Roche Pharma AG Switzerland
- Takeda Pharma AG Switzerland
Background/Aims: Insulin resistance reduces the response to interferon alfa-based therapy of chronic hepatitis C patients. It has been speculated that improvement of insulin sensitivity might increase the chances of responding to treatment of such individuals. Methods: We started a multicenter clinical trial of retreatment of chronic hepatitis C patients, who had failed to respond to the pegylated interferon alfa/ribavirin combination, with a triple therapy consisting in these same antivirals plus an insulin-sensitizer (pioglitazone) (The INSPIRED-HCV study). Results: None of the first five patients fulfilling the inclusion criteria and included in the trial achieved a satisfactory virological response after 12 weeks of retreatment, despite the fact that in at least three of them the insulin resistance score improved. As a result, the study was terminated. Conclusions: Different schedules are warranted to improve insulin sensitivity prior to attempting retreatment of chronic hepatitis C patients with insulin resistance. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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