期刊
JOURNAL OF HEPATOLOGY
卷 48, 期 5, 页码 811-820出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2007.12.022
关键词
HHT; arterio-venous malformations; liver shunts; multislice CT; echo-color-doppler; color spots; hypervascularization
Background/Aims: Hepatic arterio-venous malformations (HAVMs) have been found in 74% of hereditary hemorrhagic telangiectasia (HHT) patients with multislice CT (MSCT). This single-blind study aimed to compare the diagnostic accuracy of echo-color-Doppler with MSCT and identify the most sensitive ultrasound criteria indicating hepatic shunts. Methods: One hundred and fifty-three HHT patients were systematically screened for HAVMs by biological tests, abdominal MSCT and echo-color-Doppler. Twenty-five normal subjects and 15 cirrhotic patients were also included as control groups. Both intrahepatic (color spots and hypervascularization) and extrahepatic parameters (diameter, flow velocity and tortuosity of hepatic artery and diameter and flow velocity of portal/hepatic vein) were utilized. Color-spots are defined as subcapsular vascular spots with a high-velocity arterial blood flow and low resistivity index and can identify extremely small HAVMs. Results: CT was positive in 128/153 (84%) patients and Doppler color spots were found in 131/153 (86%) patients. The sensitivity, specificity and diagnostic accuracy of color spots compared to MSCT were 95.3%, 68.0% and 91.8%, respectively. The color-spot showed a greater correlation to CT (V-index = 0.655; p < 0.0001) than extrahepatic criteria (V = 0.317). In 20/29 (69%) subjects, echo-color-Doppler, confirmed by CT, identified the third criterion for definite HHT diagnosis. Conclusions: Intrahepatic criteria was superior to extrahepatic criteria for identification of HAVMs. A new Doppler parameter (color-spots) with an optimal accuracy for detecting HAVMs is proposed for easy periodic screening of HHT patients. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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