期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13045-014-0078-0
关键词
SINE; KPT-330; Selinexor; Nuclear export
资金
- CAHON Scholar award
- International Scholar Exchange Foundation
Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin beta superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.
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