期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13045-014-0070-8
关键词
Biomarkers; Drug development; Targeted therapies
资金
- Cancer Research U.K
- Experimental Cancer Medicine Centre
- National Institute for Health Research (NIHR) Biomedical Research Centre
- Royal Marsden NHS Foundation Trust
- Institute of Cancer Research
- Academy of Medical Sciences and British Lung Foundation
- NIHR
- Academy of Medical Sciences (AMS) [AMS-SGCL10-Yap] Funding Source: researchfish
- British Lung Foundation [RG14-3] Funding Source: researchfish
- Cancer Research UK [17782] Funding Source: researchfish
- National Institute for Health Research [CL-2012-22-001] Funding Source: researchfish
Technological advancements in the molecular characterization of cancers have enabled researchers to identify an increasing number of key molecular drivers of cancer progression. These discoveries have led to multiple novel anticancer therapeutics, and clinical benefit in selected patient populations. Despite this, the identification of clinically relevant predictive biomarkers of response continues to lag behind. In this review, we discuss strategies for the molecular characterization of cancers and the importance of biomarkers for the development of novel antitumor therapeutics. We also review critical successes and failures in oncology, and detail the lessons learnt, which may aid in the acceleration of anticancer drug development and biomarker discovery.
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