期刊
JOURNAL OF HEART AND LUNG TRANSPLANTATION
卷 29, 期 7, 页码 786-791出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2010.03.004
关键词
heat shock Protein 27; HSP; bronchiolitis obliterans syndrome; lung transplantation
资金
- National Institutes of Health [K08 HL080701]
- NSF-MCB [0542244]
- [R01 HL075040-01]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0542244] Funding Source: National Science Foundation
BACKGROUND: Heat shock proteins (Hsps) are a family of evolutionary conserved proteins classified according to their size as small and large Hsps. They have a cytoprotective role and have been shown to be immunogenic molecules. In addition, self-reactivity to Hsps has been implicated in various autoimmune diseases and in the development of alloimmunity. This study examined the relationship of large and small Hsps and anti-Hsp antibodies in lung transplant (LTx) recipients who have bronchiolitis obliterans syndrome (BOS). METHODS: Anti-Hsp27 and Hsp70 antibodies, and Hsp27, Hsp60, and Hsp70 protein expression levels were evaluated in serum and bronchoalveolar lavage samples collected from 8 LTx recipients with established BOS and 8 recipients without BOS (controls). Serum from 8 healthy individuals was examined for Hsp levels as a comparison. RESULTS: Elevated serum Hsp27 levels were observed in recipients with BOS compared with controls or healthy individuals, whereas Hsp70 and Hsp60 expression showed no difference. Anti-Hsp27 antibody levels were significantly higher in the BAL of recipients with BUS than in those without BOS. In contrast, anti-Hsp70 antibodies levels in serum or BAL showed no difference between groups. CONCLUSIONS: These results support the novel concept that Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development BOS. The expression of anti-Hsp27 antibodies found only in the BAL fluid suggests a local response occurring at the level of the alveoli and terminal airways. J Heart Lung Transplant 2010;29:786-91 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.
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