期刊
JOURNAL OF HEALTH SCIENCE
卷 55, 期 5, 页码 845-850出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/jhs.55.845
关键词
ortho-quinoid polycyclic aromatic hydrocarbon; hydrogen peroxide; redox cycle; oxidative stress; cytotoxicity
类别
资金
- Ministry of Education, Science, Sports and Culture
- Ministry of Environment, Japan for Scientific Research of ExTEND2005
The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,.10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortizo-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to co-valently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the paraquinoid PAHs were not as strong cytotoxic and did not produce H2O2.
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