期刊
JOURNAL OF HEALTH SCIENCE
卷 54, 期 6, 页码 638-644出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/jhs.54.638
关键词
6-hydroxydopamine; hydrogen peroxide; genipin; neuroprotection; Neuro2a cell
类别
资金
- Academic Frontier
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20052009]
We have previously reported that genipin, a natural iridoid compound, shows neuritogenic activity in cultured rat pheochromocytoma PC12h and mouse neuroblastoma Neuro2a cells. 6-Hydroxydopamine (6-OHDA) is a dopaminergic neurotoxin putatively involved in the pathogenesis of Parkinson's disease (PD). Here, we studied the protective effects of genipin on 6-OHDA-induced cytotoxicity in Neuro2a cells. 6-OHDA treatment markedly reduced Neuro2a cell viability in a concentration-dependent manner causing DNA condensation and fragmentation. Genipin significantly protected the cells against the 6-OHDA-induced cytotoxicity. Genipin also protected the cells against hydrogen peroxide (H2O2)-induced cytotoxicity. It is known that 6-OHDA is rapidly and non-enzymatically oxidized by molecular oxygen to form H2O2 and the corresponding p-quinone. These data suggest that genipin is effective at protecting against neurodegeneration that involves oxidative stress, such as PD.
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