期刊
JOURNAL OF HEADACHE AND PAIN
卷 9, 期 2, 页码 109-112出版社
BMC
DOI: 10.1007/s10194-008-0019-9
关键词
Chronic migraine; Medication overuse headache; MOH; Serotonin uptake; Platelets
We investigated the effect of chronic administration of different pain medications on the activity of the serotonin transporter (SERT) in patients with medication overuse headache ( MOH). We measured the kinetic of platelet 5-HT uptake ( maximal velocity, V-max and the Michaelis-Menten constant, K-m) in patients with overuse of triptans (tMOH, n = 15) or analgesics (aMOH, n = 14) before and after drug withdrawal, as well as in headache-free healthy subjects ( n = 15) and patients with episodic migraine (EM, n = 16). V-max was increased similarly in both, tMOH and aMOH compared to healthy subjects and patients with EM and normalized after withdrawal in parallel to the improvement of headache frequency. Average K-m was similar in all groups at baseline and not affected by the withdrawal. The data demonstrate a transient increase of SERT activity in patients with analgesic and triptan induced MOH but do not allow to differentiate whether the increase of serotonin uptake is caused by regular intake of analgesics or triptans or is a consequence of frequent headache attacks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据