Ultrasound-assisted dispersive solid phase nanoextraction of selected personal care products in wastewater followed by their determination using high performance liquid chromatography-diode array detector

This study reports a rapid and simple method based on ultrasound-assisted dispersive solid phase nanoextraction (UA-SPNE) method for the extraction and preconcentration of selected personal care products using MPC@Al2O3-SiO2 nano adsorbent. A high performance liquid chromatograph equipped with a diode array detector (HPLC-DAD) was used to detect the analytes of interest. Experimental parameters affecting the extraction and preconcentration efficiency of the UA-SPNE (such as mass of adsorbent, extraction time, sample pH and eluent volume,) were optimized using fractional factorial design and response surface methodology based on central composite design. Under optimized conditions, the linear range for benzophenone, N,N-diethyl-3-methylbenzamide and trichlorocarbanilide were in the interval of LOQ-1000 mu g L-1 with correlation coefficients ranged from 0.9907 to 0.9977. The limits of detection and limits of quantification were 0.066-0.096 mu g L-1 and 0.22-0.32 mu g L-1, respectively. The accuracy of the UA-SPNE/HPLC-DAD method was evaluated using spike recovery test and the recoveries were in the range of 98-107%. The repeatability and reproducibility of the method 0.8-1.0 % and 2.4-4.4%, respectively.