期刊
JOURNAL OF GLAUCOMA
卷 17, 期 4, 页码 263-268出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IJG.0b013e31815c3a7f
关键词
oxidative stress; oxidative activity; antioxidant activity; aqueous humor; glaucoma; cataracts
Purpose: To analyze oxidative stress in primary open-angle glaucoma (POAG). Material and Methods: A case-control study including 90 eyes of 90 patients who needed antiglaucomatous surgery in the course of POAG (glaucoma group, n = 50) and from patients who were operated of nonpathologic cataracts (cataract group, n = 40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test and total antioxidant status in the aqueous humor samples of both groups were determined. Statistical analyses were carried out in relation to MDA-TBARS and total antioxidant status and their correlations with glaucoma risk factors. Results: Significantly higher MDA-TBARS were detected in the POAG with respect to the comparative group of cataract subjects (P < 0.001). Antioxidant activity was significantly lower in the POAG than in the cataract group (P < 0.001). Conclusions: Aqueous humor samples may be used for determining oxidative and antioxidant status in pathologic processes. Glaucomatous eyes had a significant increase in oxidative status and decreased antioxidant activity in the aqueous humor than the cataract eyes. Oxidative stress may play a pathogenical role in the POAG.
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