期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 23, 期 4, 页码 213-227出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988710383571
关键词
Alzheimer disease; genetics; neurodegeneration
资金
- VA Puget Sound Health Care System, Seattle, Washington
- U.S. Department of Veterans Affairs
- Office of Research and Development
- Biomedical Laboratory Research Program
- NIH [T32 AG000258]
- Mental Illness Research Education and Clinical Center
- Geriatric Research Education and Clinical Center
- The University of Washington Alzheimer's Disease Research Center [NIA AG005136]
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOE epsilon 4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.
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