期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 23, 期 2, 页码 138-146出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988709358592
关键词
depression; heart failure; metabolomics
资金
- NIMH [P50 MH60451, R01 MH54846, R01 MH63211, R21 MH076178, K24 MH70027]
- NATIONAL INSTITUTE OF MENTAL HEALTH [K24MH070027, P50MH060451, R21MH076178, R01MH063211, R01MH054846] Funding Source: NIH RePORTER
Metabolomics is an emerging technology that allows researchers to characterize hundreds of small molecules that comprise the metabolome. We sought to determine metabolic differences in depressed and nondepressed participants. The sample consisted of a depressed group of patients with heart failure enrolled in an NIMH-supported clinical trial of sertraline versus placebo in depressed heart failure patients, and a nondepressed comparator group of heart failure patients. Plasma was obtained from blood samples provided by participants at baseline, and samples were profiled on GC-MS and LC-MS metabolomics platforms for biochemical content. A number of biochemicals were significantly different between groups, with depressed participants showing higher concentrations of several amino acids and dicarboxylic fatty acids. These results are consistent with prior findings where changes in neurotransmitter systems and fatty acid metabolism were shown to associate with the depressed state. It is unclear what role heart failure may have played in these differing concentrations.
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