期刊
JOURNAL OF GENETICS AND GENOMICS
卷 41, 期 3, 页码 117-123出版社
SCIENCE PRESS
DOI: 10.1016/j.jgg.2013.12.003
关键词
Homologous chromosome pairing; Orientation and segregation; Meiosis
资金
- National Basic Research Program of China (973 Program) [2011CB944601]
- National Natural Science Foundation of China [31320103912]
- USA National Science Foundation [DBI 0922703]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0922703] Funding Source: National Science Foundation
In most eukaryotic species, three basic steps of pairing, recombination and synapsis occur during prophase of meiosis I. Homologous chromosomal pairing and recombination are essential for accurate segregation of chromosomes. In contrast to the well-studied processes such as recombination and synapsis, many aspects of chromosome pairing are still obscure. Recent progress in several species indicates that the telomere bouquet formation can facilitate homologous chromosome pairing by bringing chromosome ends into close proximity, but the sole presence of telomere clustering is not sufficient for recognizing homologous pairs. On the other hand, accurate segregation of the genetic material from parent to offspring during meiosis is dependent on the segregation of homologs in the reductional meiotic division (MI) with sister kinetochores exhibiting mono-orientation from the same pole, and the segregation of sister chromatids during the equational meiotic division (MII) with kinetochores showing bi-orientation from the two poles. The underlying mechanism of orientation and segregation is still unclear. Here we focus on recent studies in plants and other species that provide insight into how chromosomes find their partners and mechanisms mediating chromosomal segregation.
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