期刊
JOURNAL OF GENETICS AND GENOMICS
卷 40, 期 6, 页码 291-296出版社
SCIENCE PRESS
DOI: 10.1016/j.jgg.2013.02.004
关键词
Small RNA; miRNA; Short tandem target mimic (STTM); Target mimic (TM); miRNA sponge; ceRNA
资金
- USDA National Research Initiative [2006-35301-17115, 2006-35100-17433]
- National Science Foundation [MCB-0718029, S-00000260, IOS-1048216/IOS-1219316]
- startup of Michigan Technological University
- National Institutes of Health [K01 DK078648, R03 DK084166]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1219316] Funding Source: National Science Foundation
MicroRNAs (miRNAs) are a population of highly conserved specific small ribo-regulators that negatively regulate gene expressions in both plants and animals. They play a key role in post-transcriptional gene regulation by destabilizing the target gene transcripts or blocking protein translation from them. Interestingly, these negative regulators are largely compromised by an upstream layer of negative regulators target mimics found in plants or endogenous competing RNAs revealed recently in animals. These endogenous regulatory mechanisms of double negatives making a positive have now been developed into a key strategy in the study of small RNA functions. This review presents some reflections on the long journey to the short tandem target mimic (STTM) for selective destruction/blockage of specific miRNAs in plants and animals, and the potential applications of STTM are discussed.
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