期刊
JOURNAL OF GENERAL VIROLOGY
卷 96, 期 -, 页码 775-781出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.000037
关键词
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资金
- Huazhong Agricultural University Scientific & Technological Self-innovation Foundation [52204-12020]
- Fundamental Research Funds for the Central Universities [2013PY069, 2014PY035]
- Wuhan Chopper Fishery Co. Ltd [720107-137076]
- Natural Science Foundation of China [31372563]
Members of the genus Vesiculovirus, which belongs to the family Rhabdoviridae, can cause great economic loss in fish culture. In the present report, a vesiculovirus [named snakehead fish vesiculovirus (SHVV)] was isolated from diseased hybrid snakehead fish. SHVV shared 94% nucleotide sequence identity at the genomic level with Siniperca chuatsi rhabdovirus (SCRV), which infects mandarin fish (S. chuatsi). We showed that SHVV was able to replicate and proliferate well in SSN-1 cells, which originate from striped snakehead fish (Channa striatus). Furthermore, mandarin fish was susceptible to SHVV by bath exposure, as well as by intraperitoneal injection. The infected fish showed typical clinical signs of rhabdovirus infection, including haemorrhage and oedema. Histopathological analysis revealed that extensive inflammation and necrosis were observed in the spleen, kidney, liver, heart and brain of the moribund mandarin fish. These results will shed new light on the epidemic of vesiculovirus infections among fish.
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