期刊
JOURNAL OF GENERAL VIROLOGY
卷 95, 期 -, 页码 1193-1210出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.062836-0
关键词
-
资金
- Wellcome Trust [089870/Z/09/Z]
- Wellcome Trust [089870/Z/09/Z] Funding Source: Wellcome Trust
- Medical Research Council [G0600006] Funding Source: researchfish
- MRC [G0600006] Funding Source: UKRI
Typical avian influenza A viruses are restricted from replicating efficiently and causing disease in humans. However, an avian virus can become adapted to humans by mutating or recombining with currently circulating human viruses. These viruses have the potential to cause pandemics in an immunologically naive human population. It is critical that we understand the molecular basis of host-range restriction and how this can be overcome. Here, we review our current understanding of the mechanisms by which influenza viruses adapt to replicate efficiently in a new host. We predominantly focus on the influenza polymerase, which remains one of the least understood host-range barriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据