期刊
JOURNAL OF GENERAL VIROLOGY
卷 94, 期 -, 页码 1658-1668出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.052142-0
关键词
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资金
- Brain Research Center of the 21st Century Frontier Research Program [2012K001130]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2012R1A1A2008018]
- Ministry of Education, Science and Technology
- Research Center for Functional Cellulomics
- KOSEF
- National Research Foundation of Korea [2012R1A1A2008018] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
NF-E2 related factor 2 (Nrf2) is a transcription factor that plays a key role(s) in cellular defence against oxidative stress. In this study, we showed that the expression of Nrf2 was upregulated in primary human foreskin fibroblasts (HFFs), following human cytomegalovirus (HCMV/HHV-5) infection. The expression of haem oxygenase-1, a downstream target of Nrf2, was also increased by HCMV infection, and this induction was suppressed in HFFs expressing a small hairpin RNA (shRNA) against Nrf2. The HCMV-mediated increase in Nrf2 expression was abolished when UV-irradiated virus was used or when the activity of casein kinase 2 was inhibited. Host cells infected by HCMV had higher survival rates following oxidative stress induced by buthionine sulfoximine compared with uninfected control cells, but this cell-protective effect was abolished by the use of Nrf2 shRNA. Our results suggest that HCMV-mediated activation of Nrf2 might be beneficial to the virus by increasing the host cell's ability to cope with oxidative stress resulting from viral infection and/or inflammation.
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