期刊
JOURNAL OF GENERAL VIROLOGY
卷 94, 期 -, 页码 263-269出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.047175-0
关键词
-
资金
- Michael Forsgren Foundation
Borna disease virus (BDV) is a neurotropic, negative-stranded RNA virus causing persistent infection and progressive neurological disorders in a wide range of warm-blooded animals. The role of the small non-structural X protein in viral pathogenesis is not completely understood. Here we investigated whether the X protein of BDV and avian bornavirus (ABV) interferes with the type I interferon (IFN) system, similar to other non-structural proteins of negative-stranded RNA viruses. In luciferase reporter assays, we found that the X protein of various bornaviruses interfered with the type I IFN system at all checkpoints investigated, in contrast to previously reported findings, resulting in reduced type I IFN secretion.
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