期刊
JOURNAL OF GENERAL VIROLOGY
卷 94, 期 -, 页码 753-757出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.048348-0
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资金
- Ligue Nationale Contre le Cancer (Comite Saone et Loire)
- Association pour la Recherche sur le Cancer (ARC)
- Agence Nationale pour la Recherche (ANR)
- Association Laurette Fugain
- Ligue Nationale Contre le Cancer (Comite de l'Ain)
- Hospices Civils de Lyon
- Lyon I University
- Institut National de la Sante et de la Recherche Medicale (INSERM)
Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4(+) and CD8(+) T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.
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