期刊
JOURNAL OF GENERAL VIROLOGY
卷 93, 期 -, 页码 341-346出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.036624-0
关键词
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资金
- National Institutes of Health [AI090196, AI081132, AI079231, AI57158, AI070411, AI090055, AI072613, EY017404]
- Defense Threat Reduction Agency
- USDA [58-1275-7-370]
We report the first identification, genetic characterization and disease association studies of several novel species of canine bocaviruses (CBoV). Evolutionary analysis confirmed that CBoV are genetically distinct from the only other known canine bocavirus, minute virus of canines, with which they share less than 63, 62 and 64% protein identity in NS, NP and VP genes, respectively. Comparative genetic analysis of 37 VP gene variants found in diseased and healthy animals showed that these novel viruses are genetically highly diverse and are common in canine respiratory infections that have remained undetected until now. Interestingly, we observed that a CBoV genotype with a unique deletion in the VP2 gene was significantly more prevalent in animals with respiratory diseases compared with healthy animals.
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