期刊
JOURNAL OF GENERAL VIROLOGY
卷 92, 期 -, 页码 1899-1905出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.031856-0
关键词
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资金
- Bundesministerium fur Bildung und Forschung [01 KI 0705]
- Deutsche Forschungsgemeinschaft [WE 2616/4, 618/4, SFB 479]
- Sino-German Center for Research Promotion [GZ 239, GZ 230]
- Swiss National Science Foundation [3100A0-118425/1]
- European Commission of the Euro-Asian SARS-DTV Network [SP22-CT-2004-511064]
- Biotechnology and Biological Sciences Research Council [BB/G012067/1] Funding Source: researchfish
- BBSRC [BB/G012067/1] Funding Source: UKRI
Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1 ''-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.
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