期刊
JOURNAL OF GENERAL VIROLOGY
卷 92, 期 -, 页码 2281-2285出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.031427-0
关键词
-
资金
- Pediatric Dengue Vaccine Initiative
- NIH [UO1 AI070343, T32 AI07404]
- Dutch Organization for Scientific research (NWO-ALW)
West Nile virus (WNV) is a member of the family Flaviviridae and is a neurotropic pathogen responsible for severe human disease. Flavivirus-infected cells release virus particles that contain variable numbers of precursor membrane (prM) protein molecules at the viral surface. Consequently, antibodies are produced against the prM protein. These antibodies have been shown to activate the infectious potential of fully immature flavivirus particles in vitro. Here, we provide in vivo proof that prM antibodies render immature WNV infectious. Infection with antibody-opsonized immature WNV particles caused disease and death of mice, and infectious WNV was found in the brains and sera.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据