期刊
JOURNAL OF GENERAL VIROLOGY
卷 91, 期 -, 页码 2947-2958出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.025205-0
关键词
-
资金
- Ministry of Science and Technology of China [2006CB933102, 2010CB530100, 2006BAD06A01]
- Chinese Academy of Sciences [KSCXL YW R 07, KSCX2-YW R 144]
There is growing evidence that porcine reproductive and respiratory syndrome virus (PRRSV) has developed mechanisms to subvert the host innate immune response PRRSV non-structural protein 2 (Nsp2) was suggested previously as a potential interferon (IFN) antagonist This study focused on Nsp2 to investigate its inhibitory mechanism of IFN induction It was demonstrated that Nsp2 strongly inhibited IFN-beta production by antagonizing activation of the IFN regulatory factor 3 (IRF-3) pathway induced by the Sendai virus (SeV) Further studies revealed that the cysteine protease domain (PL2) of Nsp2 was necessary for IFN antagonism Additionally, both full-length Nsp2 and the PL2 protease domain of Nsp2 were found to inhibit SeV-induced phosphorylation and nuclear translocation of IRF-3 These findings suggest that Nsp2 is likely to play an important role in subversion of IRF-3-dependent innate antiviral defences, providing a basis for elucidating the mechanisms underlying PRRSV pathogenesis
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