期刊
JOURNAL OF GENERAL VIROLOGY
卷 91, 期 -, 页码 2145-2151出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.022053-0
关键词
-
资金
- Medical Research Council [MC_U130115834] Funding Source: researchfish
- MRC [MC_U130115834] Funding Source: UKRI
- Medical Research Council [MC_UU_12014/6, MC_U130115834] Funding Source: Medline
Secondary envelopment of herpes simplex virus type 1 has been demonstrated as taking place at the trans-Golgi network (TGN). The inner tegument proteins pUL36 and pUL37 and the envelope glycoproteins gD and gE are known to be important for secondary envelopment We compared the cellular localizations of capsids from a virus mutant lacking the UL37 gene with those of a virus mutant lacking the genes encoding gD and gE. Although wild-type capsids accumulated at the TGN, capsids of the pUL37(-) mutant were distributed throughout the cytoplasm and showed no association with TGN-derived vesicles. This was in contrast to capsids from a gD(-)gE(-) mutant, which accumulated in the vicinity of TGN vesicles, but did not colocalize with them, suggesting that they were transported to the TGN but were unable to undergo envelopment. We conclude that the inner tegument protein pUL37 is required for directing capsids to the TGN, where secondary envelopment occurs
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据