期刊
JOURNAL OF GENERAL VIROLOGY
卷 90, 期 -, 页码 2569-2574出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.012724-0
关键词
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资金
- Defra, UK [SE1929, SE1946, SE1846, SE1945]
- French GIS prion
- EU [QLK3-CT-2002-1309]
Sheep with an ARQ/ARQ PRNP genotype at codon positions 136/154/171 are highly susceptible to experimental infection with bovine spongiform encephalopathy (BSE). However, a number of sheep challenged orally or intracerebrally with BSE were clinically asymptomatic and found to survive or were diagnosed as BSE-negative when culled. Sequencing of the full PRNP gene open reading frame of BSE-susceptible and -resistant sheep indicated that, in the majority of Suffolk sheep, resistance was associated with an M112T PRNP variant (TARO allele). A high proportion (47 of 49; 96%) of BSE-challenged wild-type (MARQ/MARQ) Suffolk sheep were BSE-infected, whereas none of the 20 sheep with at least one TARO allele succumbed to BSE. Thirteen TARO-carrying sheep challenged with BSE are still alive and some have survival periods equivalent to, or greater than, reported incubation periods of BSE in ARR/ARR and VRQ/VRQ sheep.
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