Label-free biosensing using cascaded double-microring resonators integrated with microfluidic channels

Fast and accurate quantitative measurement of biologically relevant molecules has been demonstrated for medical diagnostics and drug applications in photonic integrated circuits. Herein, we reported a highly-sensitive optical biosensor based on cascaded double-microring resonators. The sensor was integrated with microfluidic channels and investigated with its label-free detection capability. With a wavelength resolution of 0.47 nm, the measured binding capacity of the antibody on the surface exhibits reliable detection limit down to 7.10 mu g/mL using human immunoglobulin G (hIgG). (C) 2015 Elsevier B.V. All rights reserved.