期刊
JOURNAL OF GENERAL VIROLOGY
卷 90, 期 -, 页码 1353-1358出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.009431-0
关键词
-
资金
- University of Manchester OSS award
Accurate viral genotyping is important. Here I investigate genotypes in hepatitis E virus (HEV) and find that the open reading frame (ORF) structure (the lengths of three ORFs and the overlapping relationships among the ORFs) can be a good criterion for genotyping HEV. An inter-genotype recombinant (GenBank accession no. DQ450072) was revealed by analysing the ORF structure and confirmed by phylogenetic analyses. This discovery of the inter-genotype recombinant indicates that genotyping in HEV should be based on full-length sequences. The Mexican strain which is currently classified as a genotype 2 strain also exhibited the mosaic sequence pattern, although without statistical support.
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