期刊
JOURNAL OF GENERAL VIROLOGY
卷 90, 期 -, 页码 777-782出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.005041-0
关键词
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资金
- University of Sydney Medical Foundation
- Medical Research Council (UK)
- MRC [MC_U123192748] Funding Source: UKRI
- Medical Research Council [MC_U123192748] Funding Source: researchfish
Several studies have failed to demonstrate the presence of immune responses to infectious prions during the course of prion disease, reflecting the identical primary structure of normal and disease-associated isoforms and the widespread expression of the normal cellular form of prion protein, PrPc, leading to B- and/or T-cell tolerance of disease-associated isoforms and also possibly because antigen-presenting cells are unable to process the highly aggregated, detergent-insoluble, protease-resistant form, PrPSc. Under certain circumstances, PrPSc can be revealed to the immune system in immunogenic form, and it has been shown previously that anti-PrP antibodies can be induced to prions immunoadsorbed to Dynabeads using specific anti-PrP monoclonal antibodies, even in PrP-sufficient mice. This study demonstrated in a murine scrapie model that PrP-Dynabeads effectively stimulated the immune system to produce anti-PrP IgM antibodies over prolonged periods after repeated immunization. It was also shown that these immune responses prolonged incubation times in murine scrapie.
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