期刊
JOURNAL OF GENERAL PHYSIOLOGY
卷 143, 期 6, 页码 679-692出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1085/jgp.201311153
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资金
- National Institutes of Health National Heart, Lung, and Blood Institute [R37HL076795]
- National Institute of Mental Health [R01MH065531, F31MH088109]
- National Institute of Neurological Disorders and Stroke [R01NS073874]
Calmodulin regulation (calmodulation) of the family of voltage-gated Ca(V)1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca2+ sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca2+ signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca2+ feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.
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