期刊
JOURNAL OF GENERAL PHYSIOLOGY
卷 139, 期 4, 页码 261-272出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1085/jgp.201210773
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资金
- U.S. National Institutes of Health [GM 086167]
- Muscular Dystrophy Association
In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca2+) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca2+ indicator dye reveal that the amount of Ca2+ released is three-to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca2+ that binds to troponin to activate contraction is substantially smaller.
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