期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 27, 期 12, 页码 1842-1849出版社
WILEY
DOI: 10.1111/j.1440-1746.2012.07273.x
关键词
hepatitis C patients; Interleukin-10; Interleukin-28; single nucleotide polymorphisms
资金
- Egyptian Science and Technology Development Fund [1512]
Background and Aim: Recently, it has been suggested that single nucleotide polymorphisms (SNPs) in some cytokine genes may influence the production of the associated cytokines that affect the host immune response to pegylated interferon-alpha (Peg-IFN-alpha) with ribavirin (RBV) in hepatitis C virus (HCV) patients. The aim of the present study was to investigate the possible role of the SNPs of IL-10 and Il-28B and their serum levels in predicting the response to treatment of HCV-4. Methods: Egyptian patients were treated with Peg-IFN-alpha/RBV. A total of 100 HCV genotype 4-infected patients and 80 healthy control subjects were included in the present study. SNPs in the IL-10 (-592 A/C and -819 T/C) and IL-28B (rs8099917 T/G and rs12979860 C/T) genes and their serum levels were assessed. The IL-10-592-CC, IL-28-rs8099917-TT and IL-28-rs12979860-CC genotypes were significantly higher in responders than in non-responders. Results: Interestingly, the serum levels of IL-10 were significantly increased; in contrast, the serum levels of Il-28B were significantly decreased in HCV patients compared with normal patients. Polymorphisms in IL-28B are more sensitive (P?
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