期刊
JOURNAL OF GASTROENTEROLOGY
卷 54, 期 1, 页码 10-18出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00535-018-1498-3
关键词
Eosinophilic esophagitis; Fibrosis; Interleukin-13; Microenvironment; Transforming growth factor-
资金
- NIH [R01DK114436, K08DK106444]
- Molecular Pathology and Imaging Core Facility at the NIH/NIDDK [P30-DK050306]
- Host-Microbial Analytic and Repository Core Facility at the NIH/NIDDK [P30-DK050306]
- Cell Culture and iPS Core Facility at the NIH/NIDDK [P30-DK050306]
- NASPGHAN FOUNDATION/Takeda Pharmaceutical Products Inc. Research Innovation Award
- Joint Penn-CHOP Center in Digestive, Liver and Pancreatic Medicine at The Perelman School of Medicine, University of Pennsylvania
- Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)
- NIAID [U54 AI117804]
- NIDDK [U54 AI117804]
- NCATS [U54 AI117804]
- APFED
- CURED
- EFC
Eosinophilic esophagitis (EoE) is a food allergen-induced inflammatory disorder. EoE is increasingly recognized as a cause of swallowing dysfunction, food impaction and esophageal stricture. Inflammation of the esophageal mucosa involves immune cell infiltrate, reactive epithelial changes and fibroblast activation, culminating in robust tissue remodeling toward esophageal fibrosis characterized by excess collagen deposition in the subepithelial lamina propria. Fibrosis contributes to a unique mechanical property of the EoE-affected esophagus that is substantially stiffer than the normal esophagus. There is a great need to better understand the processes behind esophageal fibrosis in order to foster improved diagnostic tools and novel therapeutics for EoE-related esophageal fibrosis. In this review, we discuss the role of esophageal inflammatory microenvironment that promotes esophageal fibrosis, with specific emphasis upon cytokines-mediated functional epithelial-stromal interplays, recruitment and activation of a variety of effector cells, and tissue stiffness. We then explore the current state of clinical methodologies to detect and treat the EoE-related esophageal stricture.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据