期刊
JOURNAL OF FORENSIC SCIENCES
卷 57, 期 1, 页码 228-233出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1556-4029.2011.01913.x
关键词
forensic science; nail analysis; phenylalkylamine; micro-pulverized extraction; high-speed centrifugation; gas chromatography-mass spectrometry
资金
- Ministry of Education, Science and Technology (MEST)
- National Research Foundation (NRF) of Korea
A rapid and simple gas chromatographymass spectrometry (GCMS) method was developed and validated for the simultaneous detection and quantification of five psychotropic phenylalkylamines (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and norketamine) in toenails. After external decontamination, nail clippings were mechanically pulverized with a bead mill and then incubated in methanol under ultrasonication at 50 degrees C for 1 h. The resulting solutions were evaporated to dryness, derivatized, and analyzed by GCMS. The intra- and inter-day precisions were within 10.7% and 13.9%, respectively. The intra- and inter-day accuracies were -4.2% to 5.0% and -2.4% to 8.4%, respectively. Limits of detection and quantification for each analyte were lower than 0.024 and 0.08 ng/mg, respectively. The recoveries were in the range of 80.687.5%. The results indicated that the proposed method is a simple, rapid, accurate, and precise for quantification of five phenylalkylamines in nails. The method was successfully applied to the simultaneous detection and quantification of phenylalkylamines in nail samples of possible drug abusers.
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