期刊
JOURNAL OF FOOD BIOCHEMISTRY
卷 34, 期 -, 页码 1-14出版社
WILEY
DOI: 10.1111/j.1745-4514.2009.00282.x
关键词
-
资金
- National Natural Science Foundation of China [30671 754]
The cytotoxicity and apoptosis induction effect of 23 flavonoids on human leukemia cells (HL-60) were investigated. 3,6-Dihydroxyflavone, luteolin and geraldol showed the most potent cytotoxic effect. By comparing the cytotoxicity of selected molecules that differ in only one structure element, we identified several structural properties important for potent cytotoxic activity, including the presence of 2,3-double bond, appropriate hydroxyl numbers, 3-OH and ortho-OH in ring B. Flavonoids with a 5-OH exhibited lower cytotoxicity than their counterparts. The intracellular reactive oxygen species (ROS) detection showed that 3,6-dihydroxyflavone, luteolin and geraldol all caused ROS generation. Addition of antioxidant N-acetylcysteine prevented the elevation of ROS induced by the three flavonoids and partially suppressed their cytotoxic effects. It implied that pro-oxidation was involved in the apoptotic response, and ROS generation plays an important role in the antitumor effect of flavonoids.
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