Palladium-catalyzed intramolecular C-H bond functionalization of trifluoroacetimidoyl chloride derivatives: Synthesis of 6-trifluoromethyl-phenanthridines

Highly efficient approaches to obtain 6-trifluoromethyl-phenanthridine derivatives have been realized through the palladium-catalyzed intramolecular C-H bond functionalization of trifluoroacetimidoyl chlorides. The reaction allows the direct formation of C-sp2-C-sp2 bonds via C-H bond functionalization and rapid access to phenanthridine ring systems in moderate to high yields with good functional group tolerance. (C) 2014 Elsevier B.V. All rights reserved.