Electrochemical synthesis of methyl-3,5,7-trifluoroadamantane-1-carboxylate under recycling use of ionic liquid media

Methyl-3,5,7-trifluoroadamantane-1-carboxylate, a key intermediate for the synthesis of 1-amino-3,5,7-trifluoroadamantane (trifluoroamantadine), was synthesized by the electrochemical fluorination of methyl adamantane-1-caroxylate in pyridine-5HF under constant current conditions. After the reaction, the product was extracted from pyridine-5HF by hexane-CH2Cl2, and recovered pyridine-5HF was used repeatedly. (C) 2012 Elsevier B.V. All rights reserved.