Facile synthesis of novel fluorine containing pyrazole based thiazole derivatives and evaluation of antimicrobial activity

A series of compounds 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-ones (4a-q) were synthesized and structures of these compounds were elucidated by spectral (IR, H-1 NMR, C-13 NMR, mass spectra) analysis. Synthesized compounds were screened for in vitro antibacterial activity against the representative panel of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds were also tested for their inhibitory action against strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus). The synthesized compounds showed potent inhibitory action against the test organisms. (C) 2012 Elsevier B.V. All rights reserved.