期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 132, 期 10, 页码 792-798出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.04.023
关键词
Electrophilic difluoromethylation; Sulfoximine; Sulfoximinium; Oxidation
资金
- Loker Hydrocarbon Research Institute
Over the past decade, sulfur-based fluoromethyl containing compounds have been exhaustively investigated as versatile fluoroalkylating reagents by our research laboratory as well as many others. Lately, we have designed a novel electrophilic difluoromethylating protocol employing in situ prepared N,N-dimethyl-S-difluoromethyl-S-phenylsulfoximinium salt. The present reagent provides excellent reactivity toward a broad spectrum of nucleophilic species (N-, P-, S-, and O-nucleophiles) to yield the corresponding difluoromethylated products with high efficacy under mild conditions. Additional studies have been performed to elucidate the mechanistic fundamentals of the reactions. (C) 2011 Elsevier B.V. All rights reserved.
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