期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 132, 期 8, 页码 521-528出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.05.009
关键词
Difluorocarbene; Difluoromethylation; Chlorodifluoromethyl ketone; Chlorodifluoromethyl sulfone; Substituent effect
资金
- National Natural Science Foundation of China [20772144, 20825209, 20832008]
- Chinese Academy of Sciences
We have investigated the different chlorodifluoromethyl aryl ketones 1a-1g and sulfones 2a-2h as difluorocarbene reagents for O- and N-difluoromethylations. It was found that the sulfone reagents 2 were generally more efficient in difluoromethylation than the ketone reagents 1. Furthermore, while the different substituents on ketone reagents 1 did not show a remarkable impact on the difluoromethylation reaction, the substituent effect on the sulfone reagents 2 was much more significant. Finally, we found that p-chlorophenyl chlorodifluoromethyl sulfone 2d and p-nitrophenyl chlorodifluoromethyl sulfone 2h were among the most powerful difluorocarbene reagents in this category for O-difluoromethylations. (c) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据